Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution,
insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced …

Background Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant
(XDR) Acinetobacter baumannii, XDR Pseudomonas aeruginosa, and carbapenem …

Background Our aim was to analyze mortality attributable to carbapenem-resistant (CR)
gram-negative bacilli (GNB) in patients with bloodstream infections (BSIs). Methods …

The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …

Carbapenem-resistant Enterobacterales (CRE) remain a significant public health threat,
and, despite recent approvals, new antibiotics are needed. Severe infections caused by …

Appropriate antibiotic treatment for critically ill patients with serious Gram-negative infections
in the intensive care unit is crucial to minimize morbidity and mortality. Several new …

Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …

Background Limited data are available to guide effective antibiotic durations for hospitalized
patients with complicated urinary tract infections (cUTIs). Methods We conducted an …

Objectives: To perform a pharmacokinetic/pharmacodynamic (PK/PD) analysis of continuous-
infusion (CI) fosfomycin combined with extended-infusion (EI) cefiderocol or CI ceftazidime …