Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living
cell membranes. They have important biological functions, including maintaining plasma …

Accumulating evidence suggests that gut microbial dysbiosis is implicated in colorectal
cancer (CRC) initiation and progression through interaction with host immune system. Given …

Vitamin K is a vital micronutrient implicated in a variety of human diseases. Warfarin, a
vitamin K antagonist, is the most commonly prescribed oral anticoagulant. Patients …

In cell culture environment, some cells adhere firmly to the culture plates and may be
vulnerable to cell detachment during passage. Therefore, it is important to harvest cells with …

Cell signaling is initiated by characteristic protein patterns in the plasma membrane, but
tools to decipher their molecular organization and activation are hitherto lacking. Among the …

Mucosal head and neck squamous cell carcinoma (HNSCC) are the seventh most common
cancer, with approximately 50% of patients living beyond 5 years. Immune checkpoint …

Expression of TRAIL (tumor necrosis factor–related apoptosis–inducing ligand) by immune
cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly …

Background Sleep deprivation (SD) has been suggested to have a rapid antidepressant
effect. There is substantial evidence that neuroinflammation and neuroplasticity play critical …

Abstract The Fas/FasL system plays a central role in the physiological regulation of
apoptosis and has been implicated in the pathogenesis of several neoplasms and diseases …

CD95L (also known as FasL or CD178) is a member of the tumor necrosis family (TNF)
superfamily. Although this transmembrane ligand has been mainly considered as a potent …