Regulatory T cells in skin regeneration and wound healing

S Knoedler, L Knoedler, M Kauke-Navarro… - Military Medical …, 2023 - Springer
As the body's integumentary system, the skin is vulnerable to injuries. The subsequent
wound healing processes aim to restore dermal and epidermal integrity and functionality. To …

Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions

L Knoedler, J Dean, F Diatta, N Thompson… - Frontiers in …, 2024 - frontiersin.org
Balancing the immune response after solid organ transplantation (SOT) and vascularized
composite allotransplantation (VCA) remains an ongoing clinical challenge. While …

Modeling human anti‐pig xenoimmune responses in a pig artery tissue grafted humanized mouse model

M Fang, J Zou, F Xu, X Wang, S Hua… - …, 2023 - Wiley Online Library
Background Blood vessels that contain endothelial cells (ECs) on the surface are in direct
contact with host blood and are the first target of xenograft rejection. Currently, our …

Transcriptome profiling of immune rejection mechanisms in a porcine vascularized composite allotransplantation model

L Zhang, I Arenas Hoyos, A Helmer, Y Banz… - Frontiers in …, 2024 - frontiersin.org
Background Vascularized composite allotransplantation (VCA) offers the potential for a
biological, functional reconstruction in individuals with limb loss or facial disfigurement. Yet …

Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants

MI Ashraf, J Mengwasser, A Reutzel-Selke… - Frontiers in …, 2024 - frontiersin.org
Acute cellular rejection remains a significant obstacle affecting successful outcomes of
organ transplantation including vascularized composite tissue allografts (VCA). Donor …

Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects

A Grosu-Bularda, FV Hodea, A Cretu, FF Lita… - Journal of Clinical …, 2024 - mdpi.com
The field of plastic surgery is continuously evolving, with faster-emerging technologies and
therapeutic approaches, leading to the necessity of establishing novel protocols and solving …

Histomorphometry of the Sural Nerve for Use as a CFNG in Facial Reanimation Procedures

A Kehrer, KS Hollmann, SM Klein, AM Anker… - Journal of Clinical …, 2023 - mdpi.com
Facial palsy (FP) is a debilitating nerve pathology. Cross Face Nerve Grafting (CFNG)
describes a surgical technique that uses nerve grafts to reanimate the paralyzed face. The …

[HTML][HTML] Application possibilities of artificial intelligence in facial vascularized composite allotransplantation—a narrative review

L Knoedler, S Knoedler, O Allam, K Remy… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Facial vascularized composite allotransplantation (FVCA) is an emerging field of
reconstructive surgery that represents a dogmatic shift in the surgical treatment of patients …

Defining chronic rejection in vascularized composite allografts–do we have reliable surrogates to look for?

J Kanitakis - Current Opinion in Organ Transplantation, 2023 - journals.lww.com
The diagnosis of CR in VCA still relies mainly on clinicopathological graft alterations;
unfortunately, these become overt rather late during the rejection process, when reversal of …

Lymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation

M Kauke-Navarro, S Sadigh, CAA Lee… - Journal of Plastic …, 2024 - Elsevier
Background Apart from the skin, little is known about the immunological processes in deeper
tissues, which are typically not accessible to biopsy and inspection, of vascularized …