Background Opiate dependence is a major health and social issue in many countries. A
mainstay of therapy has been methadone maintenance treatment, but other treatments …

The National Institute on Drug Abuse Clinical Trials Network launched the Prescription
Opioid Addiction Treatment Study (POATS) in response to rising rates of prescription opioid …

Background Results of preclinical studies suggest that the GABA B receptor agonist
baclofen may be useful in treatment of opioid dependence. This study was aimed at …

Background GPs occupy a pivotal position in relation to providing services to opiate
misusers in the UK, and this is now cited to support initiatives in other countries. Aims To …

Compelling clinical evidence establishes that buprenorphine is similar to methadone in
efficacy for opiate detoxification and maintenance but safer than methadone in an overdose …

A sublingual tablet formulation of buprenorphine combining 8 mg of buprenorphine with 2
mg of naloxone is being targeted for use in settings where less than daily dosing strategies …

Opioid dependence is largely an undertreated medical condition in the United States. The
introduction of buprenorphine has created the potential to expand access to and use of …

OBJECTIVE: To review opioid dependence (OD) and its treatment. Pharmacologic
treatments, including the use of buprenorphine/naloxone, are presented. Pharmaceutical …

Objective To review the use of buprenorphine for opioid-addicted patients in primary care.
Quality of evidence The MEDLINE database was searched for literature on buprenorphine …

Background Factors associated with satisfaction among patients receiving primary care–
based buprenorphine/naloxone are unknown. Objective To identify factors related to patient …