[HTML][HTML] The current status of latency reversing agents for HIV-1 remission
A Rodari, G Darcis, CM Van Lint - Annual review of virology, 2021 - annualreviews.org
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …
[HTML][HTML] The reservoir of latent HIV
J Chen, T Zhou, Y Zhang, S Luo, H Chen… - Frontiers in cellular …, 2022 - frontiersin.org
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …
[HTML][HTML] Exosome-mediated stable epigenetic repression of HIV-1
S Shrivastava, RM Ray, L Holguin, L Echavarria… - Nature …, 2021 - nature.com
Abstract Human Immunodeficiency Virus (HIV-1) produces a persistent latent infection.
Control of HIV-1 using combination antiretroviral therapy (cART) comes at the cost of life …
Control of HIV-1 using combination antiretroviral therapy (cART) comes at the cost of life …
[HTML][HTML] Defective HIV-1 genomes and their potential impact on HIV pathogenesis
J Kuniholm, C Coote, AJ Henderson - Retrovirology, 2022 - Springer
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …
immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome …
[HTML][HTML] HIV persistence: silence or resistance?
AO Pasternak, B Berkhout - Current opinion in virology, 2023 - Elsevier
Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV)
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …
[HTML][HTML] HIV in the brain: identifying viral reservoirs and addressing the challenges of an HIV cure
Advances in antiretroviral therapy have prolonged the life of people living with HIV and
diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption …
diminished the level of virus in these individuals. Yet, HIV quickly rebounds after disruption …
[HTML][HTML] Depicting HIV-1 transcriptional mechanisms: a summary of what we know
A Dutilleul, A Rodari, C Van Lint - Viruses, 2020 - mdpi.com
Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot
be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is …
be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is …
[HTML][HTML] Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection
CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
[HTML][HTML] Transcriptional stochasticity as a key aspect of HIV-1 latency
A Damour, V Slaninova, O Radulescu, E Bertrand… - Viruses, 2023 - mdpi.com
This review summarizes current advances in the role of transcriptional stochasticity in HIV-1
latency, which were possible in a large part due to the development of single-cell …
latency, which were possible in a large part due to the development of single-cell …
The block-and-lock strategy for human immunodeficiency virus cure: lessons learned from didehydro–cortistatin A
Antiretroviral therapy effectively controls human immunodeficiency virus (HIV) infection.
However, a reservoir of latently infected cells persists under suppressive therapy …
However, a reservoir of latently infected cells persists under suppressive therapy …