Background The approaches currently used in osteoarthritis (OA) are mainly short-term
solutions with unsatisfactory outcomes. Cell-based therapies are still controversial (in terms …

Osteoarthritis is the most prevalent degenerative joint disease and one of the leading
causes of physical impairment in the world's aging population. The human lifespan has …

Accumulation of senescent chondrocytes is thought to drive inflammatory processes and
subsequent cartilage degeneration in age-related as well as posttraumatic osteoarthritis …

Background. Osteoarthritis (OA) is a common degenerative joint disease that may be closely
linked to inflammation and oxidative stress destroying the balance of cartilage matrix …

Although osteoarthritis (OA) is a chronic inflammatory degenerative disease affecting
millions of people worldwide, the current therapies are limited to palliative care and do not …

Background Osteoarthritis (OA) is a degenerative joint disease with lacking effective
prevention targets. A disintegrin and metalloproteinase with thrombospondin motifs 12 …

The ultimate goal of molecular genetic studies of human diseases is to translate the
discoveries for patient benefit. For diseases that lack licensed disease-modifying …

Ageing or obesity are risk factors for protein aggregation in the endoplasmic reticulum (ER)
of chondrocytes. This condition is called ER stress and leads to induction of the unfolded …

Temporomandibular joint (TMJ) disc degeneration is a common disease characterized by a
decrease in metabolic function. The present study aimed to investigate the pathogenesis of …

Objective Spermidine (SPD) is an anti-aging natural substance, and it exerts effects through
anti-apoptosis and anti-inflammation. However, the specific protective mechanism of SPD in …