Early detection of cancer

D Crosby, S Bhatia, KM Brindle, LM Coussens, C Dive… - Science, 2022 - science.org
Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …

Fundamentals and developments in fluorescence-guided cancer surgery

JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications

A Refaat, ML Yap, G Pietersz, APG Walsh… - Journal of …, 2022 - Springer
Advances in diagnostic imaging have provided unprecedented opportunities to detect
diseases at early stages and with high reliability. Diagnostic imaging is also crucial to …

Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

JW Bai, SQ Qiu, GJ Zhang - Signal Transduction and Targeted Therapy, 2023 - nature.com
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …

Intraoperative imaging in pathology-assisted surgery

FJ Voskuil, J Vonk, B van der Vegt, S Kruijff… - Nature biomedical …, 2022 - nature.com
The pathological assessment of surgical specimens during surgery can reduce the
incidence of positive resection margins, which otherwise can result in additional surgeries or …

Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

M Koller, SQ Qiu, MD Linssen, L Jansen… - Nature …, 2018 - nature.com
During the last decade, the emerging field of molecular fluorescence imaging has led to the
development of tumor-specific fluorescent tracers and an increase in early-phase clinical …

Targeted optical fluorescence imaging: a meta-narrative review and future perspectives

HM Schouw, LA Huisman, YF Janssen, R Slart… - European journal of …, 2021 - Springer
Purpose The aim of this review is to give an overview of the current status of targeted optical
fluorescence imaging in the field of oncology, cardiovascular, infectious and inflammatory …

[HTML][HTML] Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: a quantitative dose-escalation study

FJ Voskuil, SJ de Jongh, WTR Hooghiemstra… - Theranostics, 2020 - ncbi.nlm.nih.gov
Tumor-positive resection margins are present in up to 23% of head and neck cancer (HNC)
surgeries, as intraoperative techniques for real-time evaluation of the resection margins are …

Targeted nanobody-based molecular tracers for nuclear imaging and image-guided surgery

P Debie, N Devoogdt, S Hernot - Antibodies, 2019 - mdpi.com
Molecular imaging is paving the way towards noninvasive detection, staging, and treatment
follow-up of diseases such as cancer and inflammation-related conditions. Monoclonal …

Targeted optical imaging agents in cancer: focus on clinical applications

BP Joshi, TD Wang - Contrast media & molecular imaging, 2018 - Wiley Online Library
Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based
on biological mechanisms of disease activity. Optical imaging methods offer a number of …