The past, present, and future of antibiotics

MA Cook, GD Wright - Science translational medicine, 2022 - science.org
Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

Anti-tuberculosis treatment strategies and drug development: challenges and priorities

VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance

K Shatalin, A Nuthanakanti, A Kaushik, D Shishov… - Science, 2021 - science.org
Emergent resistance to all clinical antibiotics calls for the next generation of therapeutics.
Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide …

In situ embedding hydrogen‐bonded organic frameworks nanocrystals in electrospinning nanofibers for ultrastable broad‐spectrum antibacterial activity

Y Wang, R Cao, C Wang, X Song… - Advanced Functional …, 2023 - Wiley Online Library
In the event of a public health crisis, highly effective and sustainable antimicrobial materials
and equipment will be urgently needed. Here, the preparation is reported by electrospinning …

Bacterial outer membrane vesicles as potential biological nanomaterials for antibacterial therapy

W Huang, L Meng, Y Chen, Z Dong, Q Peng - Acta biomaterialia, 2022 - Elsevier
Antibiotic therapy is one of the most important approaches against bacterial infections.
However, the improper use of antibiotics and the emergence of drug resistance have …

Azolylpyrimidinediols as Novel Structural Scaffolds of DNA-Groove Binders against Intractable Acinetobacter baumannii

YM Tan, Y Wang, S Li, SL Zhang… - Journal of Medicinal …, 2023 - ACS Publications
A unique class of antibacterial azolylpyrimidinediols (APDs) and their analogues were
developed. Some synthesized compounds showed excellent bacteriostatic potency; …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Applications of machine learning to the problem of antimicrobial resistance: an emerging model for translational research

MN Anahtar, JH Yang, S Kanjilal - Journal of clinical microbiology, 2021 - Am Soc Microbiol
Antimicrobial resistance (AMR) remains one of the most challenging phenomena of modern
medicine. Machine learning (ML) is a subfield of artificial intelligence that focuses on the …

Nanomaterials enabling clinical translation of antimicrobial photodynamic therapy

M Awad, N Thomas, TJ Barnes, CA Prestidge - Journal of Controlled …, 2022 - Elsevier
Antimicrobial photodynamic therapy (aPDT) has emerged as a promising approach to aid
the fight against looming antibiotic resistance. aPDT harnesses the energy of light through …