The past, present, and future of antibiotics
MA Cook, GD Wright - Science translational medicine, 2022 - science.org
Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …
diseases and enable vital therapies and procedures. However, despite this success, their …
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …
biological uncertainties remain and hamper progress. However, owing to collaborative …
[HTML][HTML] Towards the sustainable discovery and development of new antibiotics
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance
Emergent resistance to all clinical antibiotics calls for the next generation of therapeutics.
Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide …
Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide …
In situ embedding hydrogen‐bonded organic frameworks nanocrystals in electrospinning nanofibers for ultrastable broad‐spectrum antibacterial activity
Y Wang, R Cao, C Wang, X Song… - Advanced Functional …, 2023 - Wiley Online Library
In the event of a public health crisis, highly effective and sustainable antimicrobial materials
and equipment will be urgently needed. Here, the preparation is reported by electrospinning …
and equipment will be urgently needed. Here, the preparation is reported by electrospinning …
Bacterial outer membrane vesicles as potential biological nanomaterials for antibacterial therapy
W Huang, L Meng, Y Chen, Z Dong, Q Peng - Acta biomaterialia, 2022 - Elsevier
Antibiotic therapy is one of the most important approaches against bacterial infections.
However, the improper use of antibiotics and the emergence of drug resistance have …
However, the improper use of antibiotics and the emergence of drug resistance have …
Azolylpyrimidinediols as Novel Structural Scaffolds of DNA-Groove Binders against Intractable Acinetobacter baumannii
YM Tan, Y Wang, S Li, SL Zhang… - Journal of Medicinal …, 2023 - ACS Publications
A unique class of antibacterial azolylpyrimidinediols (APDs) and their analogues were
developed. Some synthesized compounds showed excellent bacteriostatic potency; …
developed. Some synthesized compounds showed excellent bacteriostatic potency; …
β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium
JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …
Applications of machine learning to the problem of antimicrobial resistance: an emerging model for translational research
Antimicrobial resistance (AMR) remains one of the most challenging phenomena of modern
medicine. Machine learning (ML) is a subfield of artificial intelligence that focuses on the …
medicine. Machine learning (ML) is a subfield of artificial intelligence that focuses on the …
Nanomaterials enabling clinical translation of antimicrobial photodynamic therapy
Antimicrobial photodynamic therapy (aPDT) has emerged as a promising approach to aid
the fight against looming antibiotic resistance. aPDT harnesses the energy of light through …
the fight against looming antibiotic resistance. aPDT harnesses the energy of light through …