Metastasis, involving the spread of systemic cancer to the brain, results in neurologic
disability and death. Current treatments are largely palliative in nature; improved therapeutic …

Leptomeningeal carcinomatosis (LC) is defined as infiltration of the leptomeninges by
metastatic carcinoma, a relatively uncommon but devastating complication of many …

Purpose: ANG1005, a novel taxane derivative, consists of three paclitaxel molecules
covalently linked to Angiopep-2, designed to cross the blood–brain and blood …

Purpose: Metastasis to the brain from breast cancer remains a significant clinical challenge,
and may be targeted with CAR-based immunotherapy. CAR design optimization for solid …

Background Patients with HER2-positive breast cancer (HER2+ BC) develop central
nervous system metastases twice as often as patients with luminal HER2-negative breast …

The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor,
especially for patients with adverse prognostic factors. In this phase II clinical trial, we …

Advanced breast cancer is characterized by many physical manifestations with the potential
to undermine the quality of life (most related to the cancer and some to treatments), as well …

Effective treatments for brain tumors remain one of the most urgent and unmet needs in
modern oncology. This is due not only to the presence of the neurovascular unit/blood–brain …

Background Leptomeningeal metastasis (LM) is a rare complication of metastatic breast
cancer (MBC), with high morbidity/mortality rates. Our study aimed to describe the largest-to …

Circulating tumor DNA (ctDNA) refers to tumor-derived cell-free DNA that circulates in body
fluids. Fluid samples are easier to collect than tumor tissue, and are amenable to serial …