Applications of chitosan-based biomaterials: From preparation to spinal cord injury neuroprosthetic treatment

W Xiang, H Cao, H Tao, L Jin, Y Luo, F Tao… - International Journal of …, 2023 - Elsevier
Spinal cord injury (SCI)-related disabilities are a serious problem in the modern society.
Further, the treatment of SCI is highly challenging and is urgently required in clinical …

Spinal cord repair: from cells and tissue engineering to extracellular vesicles

S Guo, I Redenski, S Levenberg - Cells, 2021 - mdpi.com
Spinal cord injury (SCI) is a debilitating condition, often leading to severe motor, sensory, or
autonomic nervous dysfunction. As the holy grail of regenerative medicine, promoting spinal …

Encapsulation of human spinal cord progenitor cells in hyaluronan-gelatin hydrogel for spinal cord injury treatment

C Kwokdinata, V Ramanujam, J Chen… - … Applied Materials & …, 2023 - ACS Publications
Transplanting human induced pluripotent stem cells (iPSCs)-derived spinal cord progenitor
cells (SCPCs) is a promising approach to treat spinal cord injuries. However, stem cell …

The roles and applications of neural stem cells in spinal cord injury repair

W Guo, X Zhang, J Zhai, J Xue - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Spinal cord injury (SCI), which has no current cure, places a severe burden on patients.
Stem cell-based therapies are considered promising in attempts to repair injured spinal …

A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury via synergism …

W He, X Zhang, X Li, D Ju, T Mao, Y Lu, Y Gu… - Journal of Materials …, 2022 - pubs.rsc.org
Spinal cord injury (SCI), as a serious disabling disease, is still haunted by lacking of effective
treatments. We previously found that transplantation of menstrual blood-derived …

Clinical trials targeting secondary damage after traumatic spinal cord injury

ZZ Khaing, JY Chen, G Safarians, S Ezubeik… - International journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a
significant reduction in quality of life for patients. Currently, no therapies are available that …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Stem cell secretome for spinal cord repair: is it more than just a random baseline set of factors?

K Pajer, T Bellák, A Nógrádi - Cells, 2021 - mdpi.com
Hundreds of thousands of people suffer spinal cord injuries each year. The experimental
application of stem cells following spinal cord injury has opened a new era to promote …

iPSCs in neurodegenerative disorders: A unique platform for clinical research and personalized medicine

S Pandey, M Jirásko, J Lochman, A Chvátal… - Journal of personalized …, 2022 - mdpi.com
In the past, several animal disease models were developed to study the molecular
mechanism of neurological diseases and discover new therapies, but the lack of equivalent …

Hydrogel scaffolds in the treatment of spinal cord injury: a review

M Cai, L Chen, T Wang, Y Liang, J Zhao… - Frontiers in …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a disease of the central nervous system often caused by
accidents, and its prognosis is unsatisfactory, with long-term adverse effects on patients' …