Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

Principles of intracellular protein synthesis and protein degradation remain to be among the
most challenging questions of modern cell biology. Proteolysis plays an important role in …

Proteasome inhibitors are emerging as effective drugs for the treatment of multiple myeloma
and possibly certain subtypes of non-Hodgkin's lymphoma. Bortezomib (Velcade) is the first …

The proteasome inhibitor bortezomib has been approved as a cytostatic drug for the therapy
of multiple myeloma, and is currently being tested in clinical trials for a variety of other …

The proteasome is an intracellular protease complex consisting of the 20S catalytic core and
its associated regulators, including the 19S complex, PA28αβ, PA28γ, PA200, and PI31 …

Only a minority of stroke patients receive thrombolytic therapy. Therefore, new therapeutic
strategies focusing on neuroprotection are under review, among which, inhibition of the …

Rationale: The ubiquitin–proteasome system is critical for maintenance of protein
homeostasis by degrading polyubiquitinated proteins in a spatially and temporally controlled …

The giant proteolytic factory called the proteasome came a long way from a biochemical
curio to a major regulator of cellular physiology and a renowned drug target within the …

Background and Purpose—Recently, a novel locus at 17q25 was associated with white
matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the …

Aims: Determine the mechanism by which C-terminus of HSC70-interacting protein (CHIP)
induction alters neuronal survival under conditions of mitochondrial stress induced by …