Next-generation sequencing technologies have revolutionarily advanced sequence-based
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …

Since the RNA world hypothesis was proposed, a large number of regulatory noncoding
RNAs (ncRNAs) have been identified in many species, ranging from microorganisms to …

High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …

Many risk loci for Parkinson's disease (PD) have been identified by genome-wide
association studies (GWASs), but target genes and mechanisms remain largely unknown …

The functional engagement between an enhancer and its target promoter ensures precise
gene transcription. Understanding the basis of promoter choice by enhancers has important …

In this study, we used whole-genome sequencing and gene expression profiling of 215
human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic …

Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …

While genetic variation at chromatin loops is relevant for human disease, the relationships
between contact propensity (the probability that loci at loops physically interact), genetics …

Red flower color has arisen multiple times and is generally associated with hummingbird
pollination. The majority of evolutionary transitions to red color proceeded from purple …

Significant innovations in next-generation sequencing techniques and bioinformatics tools
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …