The Dual Role of Chemerin in Lung Diseases

P Lavis, B Bondue, AK Cardozo - Cells, 2024 - mdpi.com
Chemerin is an atypical chemokine first described as a chemoattractant agent for
monocytes, natural killer cells, plasmacytoid and myeloid dendritic cells, through interaction …

Advances in nanomaterial-targeted treatment of acute lung injury after burns

S Zhang, X Zhao, Y Xue, X Wang, XL Chen - Journal of …, 2024 - Springer
Acute lung injury (ALI) is a common complication in patients with severe burns and has a
complex pathogenesis and high morbidity and mortality rates. A variety of drugs have been …

Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1

PZ Mannes, TS Adams, S Farsijani, CE Barnes… - Science …, 2024 - science.org
Precision management of fibrotic lung diseases is challenging due to their diverse clinical
trajectories and lack of reliable biomarkers for risk stratification and therapeutic monitoring …

Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious …

D Stakišaitis, L Kapočius, E Kilimaitė, D Gečys… - Pharmaceutics, 2023 - mdpi.com
The research presents data from a preclinical study on the anti-inflammatory effects of a
sodium dichloroacetate and sodium valproate combination (DCA–VPA). The 2-week …

Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis

LN Moore, DL Holmes, A Sharma… - PLoS …, 2023 - journals.plos.org
Kaposi's Sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's Sarcoma (KS), a
highly vascularized tumor common in AIDS patients and many countries in Africa. KSHV is …

Chemokine receptor PET imaging: Bridging molecular insights with clinical applications

C Hunter, B Larimer - Nuclear Medicine and Biology, 2024 - Elsevier
Chemokine receptors are important components of cellular signaling and play a critical role
in directing leukocytes during inflammatory reactions. Their importance extends to numerous …

Targeted imaging of very late antigen-4 for noninvasive assessment of lung inflammation-fibrosis axis

Q Zhu, CE Barnes, PZ Mannes, JD Latoche, KE Day… - EJNMMI research, 2023 - Springer
Background The lack of noninvasive methods for assessment of dysregulated inflammation
as a major driver of fibrosis (ie, inflammation-fibrosis axis) has been a major challenge to …

Effects of Combined Treatment with Sodium Dichloroacetate and Sodium Valproate on the Genes in Inflammation-and Immune-Related Pathways in T Lymphocytes …

D Stakišaitis, L Kapočius, V Tatarūnas, D Gečys… - Pharmaceutics, 2024 - mdpi.com
The study presents data on the anti-inflammatory effects of a combination of sodium
dichloroacetate and sodium valproate (DCA–VPA) on the expression of inflammation-and …

2-deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography to Monitor Lung Inflammation and Therapeutic Response to Dexamethasone in a Murine Model of …

PZ Mannes, CE Barnes, JD Latoche, KE Day… - Molecular Imaging and …, 2023 - Springer
Purpose To image inflammation and monitor therapeutic response to anti-inflammatory
intervention using 2-deoxy-2-[18F] fluoro-D-glucose ([18F] FDG) positron emission …

Advances in multimodal imaging of lung injury

Q Zhou, Z Zhang, Y Xia, J Li, S Liu, L Fan - Chinese Journal of Academic …, 2024 - Springer
Lung injury is caused by various physical and chemical damages that lead to the destruction
of the structural integrity or dysfunction of the lungs, resulting in a series of symptoms or …