Over 30 million women living in P. falciparum endemic areas are at risk of developing
malaria during pregnancy every year. Placental malaria is characterized by massive …

Antibodies to carbohydrate epitopes are often of the IgM isotype and require multiple
binding for sufficient avidity. Therefore clusters of epitopes are preferred antigenic sites in …

Malaria is one of the top three most lethal infectious diseases in the world after tuberculosis
and HIV. The disease is caused by intracellular parasites of the genus Plasmodium spp. To …

Harnessing the therapeutic potential of immunoglobulin M (IgM) is of considerable interest in
immunotherapy due to its complement-activating and cell-agglutinating abilities …

Purpose The severity of Plasmodium falciparum infections is associated with the ability of
the infected red blood cells to cytoadhere to host vascular endothelial surfaces and to …

Molecular structure determination is important for understanding functionalities and
dynamics of macromolecules, such as proteins and nucleic acids. Cryo-electron tomography …

After transmission of infectious sporozoites from the protozoan parasite Plasmodium
falciparum by the fly Anopheles gambiae, the parasite's abundant serine synthesis …

IgM antibodies are large molecules with complex posttranslational modifications, which
possess a broad therapeutic potential. However, variations in product quality impede …

Malaria is caused by parasites of the Plasmodium family. These parasites spend part of their
life cycle replicating inside red blood cells (RBC). Malaria infects 200 million people and kills …