Description The purpose of this best practice advice article is to describe the role of Barrett's
endoscopic therapy (BET) in patients with Barrett's esophagus (BE) with dysplasia and/or …

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

Gastroesophageal reflux disease (GERD) is now one of the most common diagnoses made
in a gastroenterology practice. From a conventional pathophysiological perspective, GERD …

Objective An international meeting was organised to develop consensus on (1) the
landmarks to define the gastro-oesophageal junction (GOJ),(2) the occurrence and …

This review provides a summary of our current understanding of, and the controversies
surrounding, the diagnosis, pathogenesis, histopathology, and molecular biology of Barrett's …

Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric
carcinogenesis. The present study investigated the effects of bile acids on the induction of …

Gastroesophageal reflux is associated with adenocarcinoma in Barrett's esophagus, but the
incidence of this tumor is rising, despite widespread use of acid-suppressing medications …

Reflux esophagitis damages the squamous epithelium that normally lines the esophagus,
and promotes replacement of the damaged squamous lining by the intestinal metaplasia of …

Reflux esophagitis causes Barrett's metaplasia, an abnormal esophageal mucosa
predisposed to adenocarcinoma. Medical therapy for reflux esophagitis focuses on …

Metaplasia can result when injury reactivates latent developmental signaling pathways that
determine cell phenotype. Barrett's esophagus is a squamous-to-columnar epithelial …