Gender-affirming or cross-sex hormone therapy is integral to the management of
transgender individuals yet our appreciation of the effects of such hormones on …

Women are at increased risk for developing depression and cardiovascular disease (CVD)
across the lifespan and their comorbidity is associated with adverse outcomes that …

Objective: Cardiovascular outcome trials demonstrated that GLP-1 (glucagon-like peptide-1)
analogs including liraglutide reduce the risk of cardiovascular events in type 2 diabetes …

Androgens affect the cerebral vasculature and may contribute to sex differences in
cerebrovascular diseases. Men are at a greater risk for stroke and vascular contributions to …

Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed
cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) …

The effect of age and sex on intracranial and extracranial cerebrovascular function is poorly
understood. We investigated the relationships between age, sex, and cerebrovascular …

Peripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or
thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including …

Epidemiological studies demonstrate that there are sex differences in the incidence,
prevalence, and outcomes of cerebrovascular disease (CVD). The present study compared …

Sex and gender are important modifiers of cardiovascular system physiology,
pathophysiology, and disease development. The atherosclerosis process, together with the …

Metabolic syndrome predisposes and contributes to the development and progression of
atherosclerosis. The minipig strain “Ossabaw” is characterized by a predisposition to …