Targeted radionuclide therapy has become increasingly prominent as a nuclear medicine
subspecialty. For many decades, treatment with radionuclides has been mainly restricted to …

Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for
controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues …

“RGD” is frequently pictured as a ligand for αvβ3-integrin and useful for molecular targeting
of angiogenesis—which is about as simplistic as the idea that laser beams are green or red …

The therapeutic alliance of 177Lu radioligand therapy and immune checkpoint blockade
(ICB) has gained increasing attention. This study aims to investigate the immunomodulatory …

Purpose 68 Ga-Trivehexin is an investigational PET radiopharmaceutical (NCT05799274)
targeting αvβ6-integrin for PET imaging of carcinomas. 177 Lu-D0301 is a structurally …

Rationale: The αvβ6-and αvβ8-integrins, two cell-adhesion receptors upregulated in many
tumors and involved in the activation of the latency associated peptide (LAP)/TGFβ complex …

In a recent paper in this journal (RSC Med. Chem., 2023, 14, 2429), we described an
unusually strong impact of regiospecific exchange of phenylalanines by tyrosines in 10 …

Integrins represent ideal targets for molecular imaging and targeted therapy of cancer and
their role in cancer has been reviewed extensively elsewhere. Except for αVβ3 and αVβ5 …

Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for
controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues …

Integrins represent ideal targets for molecular imaging and targeted therapy of cancer and
their role in cancer has been reviewed extensively elsewhere. Except for aVb3 and aVb5 …