The cancer cells could be celled biomass without normal cellular regulation. They bypass
most of the signaling pathways leading to programmed cell division. On the other hand, the …

Amyloid beta (Aβ) oligomers are the most neurotoxic aggregates causing neuronal death
and cognitive damage. A detailed elucidation of the aggregation pathways from oligomers to …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which seriously
affects human health but lacks effective treatment methods. Amyloid β (Aβ) aggregates are …

Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence
of neurofibrillary tangles and amyloid plaques, the latter mainly composed of Aβ (1–40) and …

Chromobacterium violaceum is a Gram-negative, rod-shaped and opportunistic human
pathogen. C. violaceum is resistant to various antibiotics due to the production of quorum …

Amyloidopathies are the consequence of misfolding with subsequent aggregation affecting
people worldwide. Irrespective of speedy advancement in the field of therapeutics no agent …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Inhibiting
acetylcholinesterase (AChE), amyloid beta (Aβ1-42) aggregation and avoiding the oxidative …

Aβ42 peptides can form helix and sheet structure under different conditions. The
conformational conversion is closely associated with Aβ peptides aggregation and their …

Alzheimer's disease is associated with the aggregation of the misfolded neuronal peptide,
amyloid-β42 (Aβ42). Evidence has suggested that several reasons are responsible for the …

Computational study of the effect of drug candidates on intrinsically disordered biomolecules
is challenging due to their vast and complex conformational space. Here, we developed a …