Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …

Abstract Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most
preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP …

Abstract New bis-thiazole derivatives (1–10) were synthesized via the ring closure of 1, 1′-
(3, 3′-dimethoxybiphenyl-4, 4′-diyl) bis (thiourea) with phenacyl bromides and evaluated …

During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of
the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal …

In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …

In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1–
10) were synthesized and investigated for their cytotoxic effects on A549 human lung …

Pathogenic Candida and infections caused by those species are now considered as a
serious threat to public health. The treatment of candidiasis is significantly complicated by …

Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …

Background: After the approval of imatinib, more than 25 antitumor agents targeting kinases
have been approved, and several promising candidates are at various stages of clinical …