Thiazole ring—A biologically active scaffold
A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …
applications. Its derivatives have a wide range of biological activities such as antioxidant …
Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery
SR Alizadeh, SM Hashemi - Medicinal Chemistry Research, 2021 - Springer
Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents
Abstract New bis-thiazole derivatives (1–10) were synthesized via the ring closure of 1, 1′-
(3, 3′-dimethoxybiphenyl-4, 4′-diyl) bis (thiourea) with phenacyl bromides and evaluated …
(3, 3′-dimethoxybiphenyl-4, 4′-diyl) bis (thiourea) with phenacyl bromides and evaluated …
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes
Abstract Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most
preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP …
preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP …
Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …
Synthesis of new benzothiazole acylhydrazones as anticancer agents
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of
the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal …
the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal …
[HTML][HTML] Thiazole ring-the antimicrobial, anti-inflammatory, and anticancer active scaffold
S Hosseininezhad, A Ramazani - Arabian Journal of Chemistry, 2023 - Elsevier
Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …
Design, synthesis, and evaluation of a new series of thiazole-based anticancer agents as potent Akt inhibitors
In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1–
10) were synthesized and investigated for their cytotoxic effects on A549 human lung …
10) were synthesized and investigated for their cytotoxic effects on A549 human lung …
Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics
KA Demin, AG Refeld, AA Bogdanova… - Probiotics and …, 2021 - Springer
Pathogenic Candida and infections caused by those species are now considered as a
serious threat to public health. The treatment of candidiasis is significantly complicated by …
serious threat to public health. The treatment of candidiasis is significantly complicated by …
A new series of antileukemic agents: Design, synthesis, in vitro and in silico evaluation of thiazole-based ABL1 kinase inhibitors
E Zeytün, MD Altıntop, B Sever… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
Background: After the approval of imatinib, more than 25 antitumor agents targeting kinases
have been approved, and several promising candidates are at various stages of clinical …
have been approved, and several promising candidates are at various stages of clinical …