Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Chronic liver diseases from varying etiologies generally lead to liver fibrosis and cirrhosis.
Among them, non-alcoholic fatty liver disease (NAFLD) affects roughly one-quarter of the …

Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty
liver promotes liver metastasis, but the underlying mechanism remains unclear. We …

Skeletal muscle and thermogenic adipose tissue are both critical for the maintenance of
body temperature in mammals. However, whether these two tissues are interconnected to …

Metabolic dysfunction is associated with nonalcoholic steatohepatitis (NASH) development.
However, omics studies investigating metabolic changes in NASH patients are limited. In …

Adipose tissue has been shown to play a key role in energy metabolism and it has been
shown to regulate metabolic homeostasis through the secretion of adipokines. Neuregulin 4 …

The process of neutrophil extracellular traps (NETs) formation, called NETosis, is a peculiar
death modality of neutrophils, which was first observed as an immune response against …

Cisplatin (CPT) is one of the standard treatments for hepatocellular carcinoma (HCC).
However, its use is limits as a monotherapy due to drug resistance, and the underlying …

Metabolic dysfunction–associated steatohepatitis (MASH), formerly known as nonalcoholic
steatohepatitis (NASH), is an advanced stage of metabolic fatty liver disease. The …

Background & Aims The prevalence of non-alcoholic steatohepatitis (NASH)-driven
hepatocellular carcinoma (HCC) is rising rapidly, yet its underlying mechanisms remain …