Antigen receptor signaling pathways are organized by adaptor proteins. Three adaptors,
LAT, Gads, and SLP-76, form a heterotrimeric complex that mediates signaling by the T cell …

T cells in the immune system are activated by binding to foreign peptides (from an external
pathogen) or mutant peptide (derived from endogenous proteins) displayed on the surface …

Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that
has spread rapidly around the world, leading to high mortality because of multiple organ …

The T cell receptor (TCR) signaling pathway is an ensemble of numerous proteins that are
crucial for an adequate immune response. Disruption of any protein involved in this pathway …

GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a
wide array of binding partners. GRB2 has been reported to exist in either a monomeric or …

Increased susceptibility to develop severe forms of Epstein-Barr virus (EBV) infection in early
age is a significant hallmark of an underlying primary immunodeficiency (PID). Here, we …

The propagation and diversification of signals downstream of the T cell receptor (TCR)
involve several adaptor proteins that control the assembly of multimolecular signaling …

Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein that plays a critical role
in cellular signal transduction. It contains a central Src homology 2 (SH2) domain flanked by …

The costimulatory receptor CD28 synergizes with the TCR to promote IL-2 production, cell
survival, and proliferation; yet the obligatory interdependence of TCR and CD28 signaling is …

AFFINImeter [1] is a shareware software for the general analysis of binding experiments. It
was born upon the need of a tool for the analysis of isothermal titration calorimetry (ITC) …