Copper-induced cell death, also known as cuproptosis, is distinct from other types of cell
death such as apoptosis, necrosis, and ferroptosis. It can trigger the accumulation of lethal …

The p53 tumor suppressor protein plays an important role in physiological and pathological
processes. MDM2 and its homolog MDMX are the most important negative regulators of p53 …

OBJECTIVE The relationship between brain metastasis resection and risk of nodular
leptomeningeal disease (nLMD) is unclear. This study examined genomic alterations found …

As a highly malignant tumor, the morbidity and mortality of cutaneous melanoma (CM) are
increasing year by year. A novel type of cell death connected to mitochondrial metabolism is …

Glioblastoma multiforme (GBM) is a brain tumor notorious for its propensity to recur after the
standard treatments of surgical resection, ionizing radiation (IR), and temozolomide (TMZ) …

The present study was the first comprehensive investigation of genetic mutation and
expression levels of the p53 signaling genes in cutaneous melanoma through various …

MDM4 is one of the MDM protein family and is generally recognized as the key negative
regulator of p53. As a cancer-promoting factor, it plays a non-negligible role in …

Background While genetic alterations in brain metastases (BMs) have been previously
explored, there are limited data examining their association with recurrence after surgical …

Current studies in early cancer detection based on liquid biopsy data often rely on off-the-
shelf models and face challenges with heterogeneous data, as well as manually designed …

MDM2 and MDM4 proteins are key negative regulators of tumor suppressor p53. MDM2 and
MDM4 interact via their RING domains and form a heterodimer polyubiquitin E3 ligase …