Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders
U Neniskyte, CT Gross - Nature Reviews Neuroscience, 2017 - nature.com
The final stage of brain development is associated with the generation and maturation of
neuronal synapses. However, the same period is also associated with a peak in synapse …
neuronal synapses. However, the same period is also associated with a peak in synapse …
Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …
significant clinical, social and financial impacts for patients and their communities. The …
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …
Associations between gut microbiota and Alzheimer's disease, major depressive disorder, and schizophrenia
Background Growing evidence has shown that alterations in the gut microbiota composition
were associated with a variety of neuropsychiatric conditions. However, whether such …
were associated with a variety of neuropsychiatric conditions. However, whether such …
An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis
N Çakici, NJM Van Beveren, G Judge-Hundal… - Psychological …, 2019 - cambridge.org
BackgroundAccumulating evidence shows that a propensity towards a pro-inflammatory
status in the brain plays an important role in schizophrenia. Anti-inflammatory drugs might …
status in the brain plays an important role in schizophrenia. Anti-inflammatory drugs might …
Neurogenesis after stroke: a therapeutic perspective
Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies
available to treat stroke are very limited. There is an urgent need to develop novel …
available to treat stroke are very limited. There is an urgent need to develop novel …
Maternal immune activation in neurodevelopmental disorders
Converging lines of evidence from basic science and clinical studies suggest a relationship
between maternal immune activation (MIA) and neurodevelopmental disorders such as …
between maternal immune activation (MIA) and neurodevelopmental disorders such as …
Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia
F Corsi-Zuelli, B Deakin - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
It is widely held that schizophrenia involves an active process of peripheral inflammation that
induces or reflects brain inflammation with activation of microglia, the brain's resident …
induces or reflects brain inflammation with activation of microglia, the brain's resident …
The role of microglia in neuropsychiatric disorders and suicide
This narrative review examines the possible role of microglial cells, first, in
neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research …
neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research …
[HTML][HTML] Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system
N Lannes, E Eppler, S Etemad, P Yotovski, L Filgueira - Oncotarget, 2017 - ncbi.nlm.nih.gov
Microglia cells are the unique residential macrophages of the central nervous system (CNS).
They have a special origin, as they derive from the embryonic yolk sac and enter the …
They have a special origin, as they derive from the embryonic yolk sac and enter the …