Macrophages in atherosclerosis regression
TJ Barrett - Arteriosclerosis, thrombosis, and vascular biology, 2020 - Am Heart Assoc
Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …
[HTML][HTML] Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer
Despite objective responses to poly (ADP-ribose) polymerase (PARP) inhibition and
improvements in progression-free survival (PFS) compared to standard chemotherapy in …
improvements in progression-free survival (PFS) compared to standard chemotherapy in …
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
[HTML][HTML] Macrophage biology and mechanisms of immune suppression in breast cancer
AK Mehta, S Kadel, MG Townsend, M Oliwa… - Frontiers in …, 2021 - frontiersin.org
Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend
against pathogens; however, their infiltration into tumors has been associated with adverse …
against pathogens; however, their infiltration into tumors has been associated with adverse …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
Cholesterol transport system: an integrated cholesterol transport model involved in atherosclerosis
XH Yu, DW Zhang, XL Zheng, CK Tang - Progress in Lipid Research, 2019 - Elsevier
Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …
[HTML][HTML] 7-Ketocholesterol in disease and aging
A Anderson, A Campo, E Fulton, A Corwin… - Redox biology, 2020 - Elsevier
Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …
[HTML][HTML] Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells
N Mukhamedova, A Hoang, D Dragoljevic… - PLoS …, 2019 - journals.plos.org
HIV infection has a profound effect on “bystander” cells causing metabolic co-morbidities.
This may be mediated by exosomes secreted by HIV-infected cells and containing viral …
This may be mediated by exosomes secreted by HIV-infected cells and containing viral …
The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism
Abstract Poly (ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …
repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and …