Piperacillin/tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity encompassing most Gram-positive and Gram-negative …

Knowledge of the management of infections of the deep spaces of the neck is essential to
the daily practice of oral and maxillofacial surgery. Timely decisions must be made through …

Deep neck infections continue to be seen despite the wide use of antibiotics. These
infections follow along fascial planes to create deep neck space abscesses. The clinical …

Nosocomial pneumonia and acute peritonitis may be caused by a wide array of pathogens,
and combination therapy is often recommended. We have previously shown that imipenem …

Violacein is a bisindole antibiotic that is effective against Gram-positive bacteria while the
bacterial predator, Bdellovibrio bacteriovorus HD100, predates on Gram-negative strains. In …

The emergence of antimicrobial resistant strains bacteria and a decline in the discovery of
new antibiotics has led to the idea of combining various antimicrobials to treat resistant …

Clavulanic acid is a potent mechanism-based inhibitor of TEM-1 and SHV-1β-lactamases,
enzymesthatconferresistancetoβ-lactamsinmany Gram-negative pathogens. This compound …

There are both pharmacodynamic and evolutionary reasons to use multiple rather than
single antibiotics to treat bacterial infections; in combination antibiotics can be more effective …

Bacterial resistance to β-lactam/β-lactamase inhibitor combinations by single amino acid
mutations in class A β-lactamases threatens our most potent clinical antibiotics. In TEM-1 …

The efficacy of piperacillin/tazobactam at 100/12.5 mg/kg every 8 h (35 patients) was
compared to cefotaxime plus metronidazole at 50/7.5 mg/kg every 8 h (35 patients) in 70 …