[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy

M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

[HTML][HTML] Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

[HTML][HTML] Advancing application of mesenchymal stem cell-based bone tissue regeneration

F Shang, Y Yu, S Liu, L Ming, Y Zhang, Z Zhou, J Zhao… - Bioactive materials, 2021 - Elsevier
Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

[HTML][HTML] Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

Challenges in clinical development of mesenchymal stromal/stem cells: concise review

I Mastrolia, EM Foppiani, A Murgia… - Stem cells …, 2019 - academic.oup.com
Identified 50 years ago, mesenchymal stromal/stem cells (MSCs) immediately generated a
substantial interest among the scientific community because of their differentiation plasticity …

Developing biodegradable lipid nanoparticles for intracellular mRNA delivery and genome editing

M Qiu, Y Li, H Bloomer, Q Xu - Accounts of chemical research, 2021 - ACS Publications
Conspectus Since the US Food and Drug Administration (FDA) granted emergency use
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …

Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy

DC Ding, YH Chang, WC Shyu, SZ Lin - Cell transplantation, 2015 - journals.sagepub.com
The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs).
Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster …

[HTML][HTML] Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow …

L Xu, Y Liu, Y Sun, B Wang, Y Xiong, W Lin… - Stem cell research & …, 2017 - Springer
Abstract Background Mesenchymal stem cells (MSCs) possess intrinsic regeneration
capacity as part of the repair process in response to injury, such as fracture or other tissue …