The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

Onconephrology is an upcoming and expanding subspecialty that deals with the
intersections between hematology/oncology and nephrology. With the paradigm shift in the …

Various types of systemic amyloidosis can wreak havoc on the architecture and functioning
of the kidneys. Amyloidosis should be suspected in patients with worsening kidney function …

AL amyloidosis is caused by the excessive production of nonfunctional immunoglobulins,
leading to the formation of amyloid fibrils that damage vital organs, especially the heart and …

Monoclonal gammopathy of renal significance (MGRS) defines disorders characterized by
direct or indirect kidney injury caused by a monoclonal immunoglobulin produced by a B …

Kidney transplantation is the ideal treatment modality for patients with end-stage kidney
disease, with excellent outcomes post-transplant compared with dialysis. However, kidney …

Amyloid light-chain (AL) amyloidosis is a rare hematological disease that produces
abnormal monoclonal immunoglobulin light chains to form amyloid fibrils that are deposited …

Light chain amyloidosis is a plasma–cell disorder with a poor prognosis. It is a progressive
condition, causing worsening pain, disability, and life-limiting complications involving …

Amyloidosis is a heterogeneous disorder characterized by abnormal protein aggregate
deposition that often leads to kidney involvement and end-stage kidney disease. With …

Background: The morbidity and mortality from AL amyloidosis has significantly improved
with the development of novel treatments. Daratumumab is a highly effective treatment for …