Endothelial dysfunction, inflammation and coronary artery disease: potential biomarkers and promising therapeutical approaches

DJ Medina-Leyte, O Zepeda-García… - International journal of …, 2021 - mdpi.com
Coronary artery disease (CAD) and its complications are the leading cause of death
worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the …

Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors

JL Silveira Rossi, SM Barbalho… - Diabetes/Metabolism …, 2022 - Wiley Online Library
Metabolic syndrome (MS) is a chronic non‐infective syndrome characterised clinically by a
set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity …

[HTML][HTML] Use of human umbilical vein endothelial cells (HUVEC) as a model to study cardiovascular disease: A review

DJ Medina-Leyte, M Domínguez-Pérez, I Mercado… - Applied Sciences, 2020 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …

[HTML][HTML] Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment

SR Botts, JE Fish, KL Howe - Frontiers in pharmacology, 2021 - frontiersin.org
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

[HTML][HTML] Metformin, macrophage dysfunction and atherosclerosis

X Feng, W Chen, X Ni, PJ Little, S Xu, L Tang… - Frontiers in …, 2021 - frontiersin.org
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Nrf2 and heme oxygenase-1 involvement in atherosclerosis related oxidative stress

JA Alonso-Piñeiro, A Gonzalez-Rovira… - Antioxidants, 2021 - mdpi.com
Atherosclerosis remains the underlying process responsible for cardiovascular diseases
and the high mortality rates associated. This chronic inflammatory disease progresses with …

Statin-induced nitric oxide signaling: mechanisms and therapeutic implications

AM Gorabi, N Kiaie, S Hajighasemi, M Banach… - Journal of clinical …, 2019 - mdpi.com
In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects
including improvements in heart failure (HF), reduced blood pressure, prevention of the …

Natural products: The role and mechanism in low‐density lipoprotein oxidation and atherosclerosis

S Zhang, L Li, W Chen, S Xu, X Feng… - Phytotherapy …, 2021 - Wiley Online Library
Atherosclerosis is a chronic inflammatory, metabolic, and epigenetic disease, which leads to
the life‐threatening coronary artery disease. Emerging studies from bench to bedside have …

[HTML][HTML] Autophagy, pyroptosis, and ferroptosis: new regulatory mechanisms for atherosclerosis

L Lin, MX Zhang, L Zhang, D Zhang, C Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Atherosclerosis is a chronic inflammatory disorder characterized by the gradual buildup of
plaques within the vessel wall of middle-sized and large arteries. The occurrence and …

Curcumin as a natural remedy for atherosclerosis: a pharmacological review

L Singh, S Sharma, S Xu, D Tewari, J Fang - Molecules, 2021 - mdpi.com
Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows
potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties …