Proline-rich peptides are a chemically and structurally diverse family of cell-penetrating
vectors characterised by the presence of pyrrolidine rings from prolines. Amphipathic Pro …

During the last decade, cell-penetrating peptides have been investigated for their ability to
overcome the plasma membrane barrier of mammalian cells for the intracellular or …

Leukemia is a hematological malignancy associated with the uncontrolled proliferation of
mutant progenitors, suppressing the production of normal blood cells. Current treatments …

The recent discovery of new potent therapeutic molecules which do not reach the clinic due
to poor delivery and low bioavailability have made of delivery a key stone in therapeutic …

The cell membrane is a highly selective barrier. This limits the cellular uptake of molecules
including DNA, oligonucleotides, peptides and proteins used as therapeutic agents …

The efficient and non-toxic nuclear delivery of steric-block oligonucleotides (ON) is a
prerequisite for therapeutic strategies involving splice correction or exon skipping. Cationic …

Millions of children and young adults are exposed to fine particulate matter (PM 2.5) and
ozone, associated with Alzheimer's disease (AD) risk. Mexico City (MC) children exhibit …

Murine bone marrow macrophages were able to recognize gold nanoparticle peptide
conjugates, while peptides or nanoparticles alone were not recognized. Consequently, in …

An exciting and emerging field in nanomedicine involves the use of gold nanoparticles
(AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of …

Nanoparticle-and quantum-dot (QD)-based bioprobes are emerging as alternatives to small-
molecule probes for in vitro and in vivo applications. However, their cellular interaction and …