The discovery of RNA interference (RNAi) has excited the scientific field due to its potential
for wide range of therapeutic applications. The pharmacological mediator of RNAi, short …

Amphiphilic molecules, forming self-assembled nanoarchitectures, are typically composed
of hydrophobic and hydrophilic domains. Peptide amphiphiles can be designed from two …

Abstract Cell-penetrating peptides (CPPs), often vividly termed as the “Trojan Horse”
peptides, have attracted considerable interest for the intracellular delivery of a wide range of …

Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

Antisense oligonucleotides (ASOs) have the potential to revolutionize medicine due to their
ability to manipulate gene function for therapeutic purposes. ASOs are chemically modified …

The dramatic acceleration in identification of new nucleic-acid-based therapeutic molecules
has provided new perspectives in pharmaceutical research. However, their development is …

The number of protein-based drugs is exponentially increasing. However, development of
protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic …

Importance of the field: More than 10 million people worldwide are diagnosed with cancer
each year, and the development of effective cancer treatments is consequently of great …

Membrane interaction constitutes to be an essential parameter in the mode of action of
entities such as proteins, as well as cell-penetrating and antimicrobial peptides, resulting in …