The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …

Stress is an adaptive response to environment aversive stimuli and a common life
experience of one's daily life. Chronic or excessive stress especially that happened in early …

Mood disorders affect nearly a quarter of the world's population. Therefore, understanding
the molecular mechanisms underlying these conditions is of great importance. FK-506 …

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The
prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …

Purpose Here, we explore the involvement of FKBP51 in glucocorticoid-induced insulin
resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in …

A key challenge in studying organisms and diseases is to detect rare molecular programs
and rare cell populations that drive development, differentiation and transformation …

Depression, type 2 diabetes (T2D), and metabolic syndrome (MetS) are often comorbid.
Depression per se increases the risk for T2D by 60%. This risk is not accounted for by the …

The hypothalamus-pituitary-adrenal (HPA) axis directly controls the stress response.
Dysregulation of this neuroendocrine system is a common feature among psychiatric …

Background FK506-binding proteins (FKBPs) have become the subject of considerable
interest in several fields, leading to the identification of several cellular and molecular …

This review portraits FK506 binding protein (FKBP) 51 as “reactivity protein” and collates
recent publications to develop the concept of FKBP51 as contributor to different levels of …