Blood vessels are lined by a single layer of endothelial cells that provide a barrier between
circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly …

Stable angina pectoris (SAP) is a prevalent condition characterised by a high disease
burden. Based on recent evidence, the need for revascularisation in addition to optimal …

Bacterial infections frequently occur within or near the vascular network as the vascular
network connects organ systems and is essential in delivering and removing blood …

Abstract Mitochondrial calcium (mCa2+) uptake occurs via the Mitochondrial Ca2+ Uniporter
(MCU) complex and plays a critical role in mitochondrial dynamics, mitophagy, and …

In vitro cell cultures are fundamental and necessary tools in cancer research and
personalized drug discovery. Currently, most cells are cultured using two-dimensional (2D) …

Atherosclerotic plaques are commonly observed at low shear regions, in particular, the left
main coronary artery (LMCA) bifurcation. Low shear regions at bifurcations promote …

Shear stress during bioreactor cultivation has significant impact on cell health, growth, and
fate. Mammalian cells, such as T cells and stem cells, in next-generation cell therapies are …

Epigenomic changes in the venous cells exerted by oscillatory shear stress towards the
endothelium may result in consolidation of gene expression alterations upon vein wall …

Early atherosclerotic lesions often develop in areas of disturbed flow within arterial
curvatures and bifurcations. Complex flows alter the signaling of inflammatory and other …

The Starling principle is a model that explains the transvascular distribution of fluids
essentially governed by hydrostatic and oncotic forces, which dynamically allow vascular …