Neurological diseases are complex diseases affecting the brain and spinal cord, with
numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook …

With the progress of medicine, especially in the last century, life expectancy increased
considerably. As a result, age-related diseases also increased, especially malignancies and …

Background Spinal cord injury (SCI) is a traumatic injury to the central nervous system and
can cause lipid peroxidation in the spinal cord. Ferroptosis, an iron-dependent programmed …

Spinal cord injury (SCI) is a debilitating condition that results in significant impairment of
motor function and sensation. Despite the ongoing efforts to develop effective treatments …

Celastrol is a promising antitumor drug candidate, but the poor water solubility and
cytotoxicity limit its clinical application. Herein, we synthesized a Celastrol (Cel)-chitosan …

Neurological ailments, including stroke, Alzheimer's disease (AD), epilepsy, Parkinson's
disease (PD), and other related diseases, have affected around 1 billion people globally to …

Celastrol is a quinone methyl triterpenoid monomeric ingredient extracted from the root of
Tripterygium wilfordii. Celastrol shows potential pharmacological activities in various …

Background Parkinson's disease (PD) is a neurological disorder. Recently, celastrol (Cel)
has been reported to have neuroprotective properties. We investigated the protective effects …

Tripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by
the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is …

TJP1, an adaptor protein of the adhesive barrier, has been found to exhibit distinct
oncogenic or tumor suppressor functions in a cell-type dependent manner. However, the …