Scientific rationale for developing potent RBD-based vaccines targeting COVID-19
H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …
moral challenge. Despite the rapid development and authorization of several full-length …
Advances in SARS-CoV-2 receptor-binding domain-based COVID-19 vaccines
ABSTRACT Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has caused
devastating human and economic costs. Vaccination is an important step in controlling the …
devastating human and economic costs. Vaccination is an important step in controlling the …
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity
BL Hartwell, MB Melo, P Xiao, AA Lemnios… - Science translational …, 2022 - science.org
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization
strategies are needed that elicit protection at mucosal portals of pathogen entry …
strategies are needed that elicit protection at mucosal portals of pathogen entry …
An aluminum hydroxide: CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice
E Nanishi, F Borriello, TR O'Meara… - Science translational …, 2021 - science.org
Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …
SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques
NC Dalvie, LH Tostanoski, SA Rodriguez-Aponte… - Science …, 2022 - science.org
Authorized vaccines against SARS-CoV-2 remain less available in low-and middle-income
countries due to insufficient supply, high costs, and storage requirements. Global immunity …
countries due to insufficient supply, high costs, and storage requirements. Global immunity …
Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds
Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize
antigens and enhance humoral immunity through multivalent antigen display. However, P …
antigens and enhance humoral immunity through multivalent antigen display. However, P …
[HTML][HTML] An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen
M Limonta-Fernández, G Chinea-Santiago… - New …, 2022 - Elsevier
Developing affordable and easily manufactured SARS-CoV-2 vaccines will be essential to
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …
Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
JY Wang, A Khmelinskaia, W Sheffler… - Proceedings of the …, 2023 - National Acad Sciences
Computationally designed protein nanoparticles have recently emerged as a promising
platform for the development of new vaccines and biologics. For many applications …
platform for the development of new vaccines and biologics. For many applications …
Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants
J Logue, RM Johnson, N Patel, B Zhou… - Nature …, 2023 - nature.com
SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission
K Tabynov, N Turebekov, M Babayeva, G Fomin… - npj Vaccines, 2022 - nature.com
Recombinant protein approaches offer major promise for safe and effective vaccine
prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine …
prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine …