It is extensively verified that continued oxidative stress and oxidative damage may lead to
chronic inflammation, which in turn can mediate most chronic diseases including cancer …

Cardiovascular disease is the main cause of early death in the settings of chronic kidney
disease (CKD), type 2 diabetes mellitus (T2DM), and ageing. Cardiovascular events can be …

The intestinal barrier is complex and consists of multiple layers, and it provides a physical
and functional barrier to the transport of luminal contents to systemic circulation. While the …

Stimuli-responsive in situ self-assembly of small molecules to form nanostructures in living
subjects has produced promising tools for molecular imaging and tissue engineering …

High ambient temperature has multiple potential effects on the organism such as
hyperthermia, endotoxemia, and/or systemic inflammation. However, it is often difficult to …

Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic
low grade inflammation that underlies many chronic diseases. Here we show that mice fed a …

Effective gastrointestinal functionality is crucial in determining animal health, welfare and
performance. A new definition of gastrointestinal functionality has been recently presented …

Sepsis is a potentially fatal condition caused by dysregulation of the body's immune
response to an infection. Sepsis-induced liver injury is considered a strong independent …

Background Understanding the mechanism of the sexual dimorphism in susceptibility to
obesity and metabolic syndrome (MS) is important for the development of effective …

The present review examines the pig as a model for physiological studies in human subjects
related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and …