Current understanding of the pathogenesis of progressive chronic kidney disease in cats

RE Jepson - Veterinary Clinics: Small Animal Practice, 2016 - vetsmall.theclinics.com
Chronic kidney disease (CKD) is a common condition identified in cats at both general
practice and the referral level. The term CKD is used to imply alteration in structure or …

How acute kidney injury contributes to renal fibrosis

L Yang - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
Acute kidney injury (AKI) is a widespread clinical syndrome directly associated with patient
short-term and long-term morbidity and mortality. During the last decade, the incidence rate …

The combined effect of zinc oxide nanoparticles and milrinone on acute renal ischemia/reperfusion injury in rats: Potential underlying mechanisms

EM Embaby, RM Saleh, BH Marghani, N Barakat… - Life Sciences, 2023 - Elsevier
Aim To investigate the efficacy of zinc oxide nanoparticles (ZnO-NPs) and/or milrinone (MIL)
on renal ischemia/reperfusion injury (I/RI) in rats and their possible underlying mechanisms …

Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease

S Spencer, C Wheeler‐Jones… - Journal of veterinary …, 2020 - Wiley Online Library
There is a growing body of experimental and clinical evidence supporting mineralocorticoid
receptor (MR) activation as a powerful mediator of renal damage in laboratory animals and …

AIM associated with the IgM pentamer: attackers on stand-by at aircraft carrier

T Miyazaki, T Yamazaki, R Sugisawa… - Cellular & molecular …, 2018 - nature.com
Circulating immunoglobulin M (IgM) exists in a pentameric form, possessing a polyreactive
nature that responds not only to foreign antigens but also to autoantigens; thus, it is involved …

[HTML][HTML] The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro …

JS Lawson, HH Liu, HM Syme, R Purcell… - PLoS …, 2018 - journals.plos.org
Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is
pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both …

Efficacy of allogeneic mesenchymal stem cell administration in a model of acute ischemic kidney injury in cats

DD Rosselli, JL Mumaw, V Dickerson, CA Brown… - Research in veterinary …, 2016 - Elsevier
Objective To evaluate the effects of allogeneic mesenchymal stem cells (MSCs) in a model
of ischemic acute kidney injury (AKI). Study design Randomized controlled trial. Animals …

Expression of kidney injury molecule-1 in healthy and diseased feline kidney tissue

SK Bland, CW Schmiedt, ME Clark… - Veterinary …, 2017 - journals.sagepub.com
Sensitive markers to detect acute kidney injury (AKI) in cats are lacking. Kidney injury
molecule-1 (KIM-1) is a promising marker of acute tubular injury in humans, and sequence …

Long‐term outcome of dogs recovering from acute kidney injury: 132 cases

M Bar‐Nathan, H Chen, D Rimer… - Journal of Veterinary …, 2022 - Wiley Online Library
Background Information regarding long‐term outcome of dogs recovering from acute kidney
injury (AKI) is limited. Objectives Determine the long‐term outcome of dogs recovering from …

Hypoxia and chronic kidney disease: Possible mechanisms, therapeutic targets, and relevance to cats

S Spencer, C Wheeler-Jones, J Elliott - The Veterinary Journal, 2021 - Elsevier
There is mounting evidence that kidney ischaemia/hypoxia plays an important role in feline
chronic kidney disease (CKD) development and progression, as well as in human disease …