Relevance and regulation of cell density

GE Neurohr, A Amon - Trends in cell biology, 2020 - cell.com
Cell density shows very little variation within a given cell type. For example, in humans
variability in cell density among cells of a given cell type is 100 times smaller than variation …

[HTML][HTML] Diverse relations between ABC transporters and lipids: An overview

J Neumann, D Rose-Sperling, UA Hellmich - Biochimica et Biophysica Acta …, 2017 - Elsevier
It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette
(ABC) transporter, can transport phospholipids such as phosphatidylcholine,− ethanolamine …

The distribution of cellular turnover in the human body

R Sender, R Milo - Nature medicine, 2021 - nature.com
We integrated ubiquity, mass and lifespan of all major cell types to achieve a comprehensive
quantitative description of cellular turnover. We found a total cellular mass turnover of 80±20 …

Metabolic regulation of species-specific developmental rates

M Diaz-Cuadros, TP Miettinen, OS Skinner, D Sheedy… - Nature, 2023 - nature.com
Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …

Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions

OS Skinner, J Blanco-Fernández, RP Goodman… - Nature …, 2023 - nature.com
Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …

Robust surface-to-mass coupling and turgor-dependent cell width determine bacterial dry-mass density

ER Oldewurtel, Y Kitahara… - Proceedings of the …, 2021 - National Acad Sciences
During growth, cells must expand their cell volumes in coordination with biomass to control
the level of cytoplasmic macromolecular crowding. Dry-mass density, the average ratio of …

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

SY Lunt, V Muralidhar, AM Hosios, WJ Israelsen… - Molecular cell, 2015 - cell.com
Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms
on tumor cells has been extensively studied, but whether PKM2 is required for normal cell …

High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays

N Cermak, S Olcum, FF Delgado, SC Wasserman… - Nature …, 2016 - nature.com
Methods to rapidly assess cell growth would be useful for many applications, including drug
susceptibility testing, but current technologies have limited sensitivity or throughput. Here we …

A systematic evaluation of methods for tailoring genome-scale metabolic models

S Opdam, A Richelle, B Kellman, S Li, DC Zielinski… - Cell systems, 2017 - cell.com
Genome-scale models of metabolism can illuminate the molecular basis of cell phenotypes.
Since some enzymes are only active in specific cell types, several algorithms use omics data …

Physiological basis for atmospheric methane oxidation and methanotrophic growth on air

T Schmider, AG Hestnes, J Brzykcy, H Schmidt… - Nature …, 2024 - nature.com
Atmospheric methane oxidizing bacteria (atmMOB) constitute the sole biological sink for
atmospheric methane. Still, the physiological basis allowing atmMOB to grow on air is not …