The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …

The development of cancer is due to the accumulation of multiple somatic mutations and in
some cases due to germline mutations, which occur in malignancies such as retinoblastoma …

The epidermal growth factor receptor (EGFR) is a promising target for anticancer therapy
because of its role in tumor growth, metastasis and angiogenesis, and tumor resistance to …

Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling
processes in the cells of the immune system. Uncontrolled signaling from receptor tyrosine …

Although multitargeted PtIV anticancer prodrugs have shown significant activities in
reducing drug resistance, the types of bioactive ligands and drugs that can be conjugated to …

Metallodrugs have a central role in the treatment and diagnosis of diseases. To overcome
potential toxicity and equip metal-based anticancer agents with biological activity, the choice …

Seven isoflavones, biochanin A, daidzein, genistein, genistin, prunectin, puerarin, and
pseudobaptigenin were tested for cytostatic and cytotoxic effects on 10 newly established …

Phosphorylation of tyrosine residues on the epidermal growth factor (EGF) receptor (EGFr) is
an important early event in signal transduction, leading to cell replication for major human …

Many excellent and up to date reviews on kinase inhibitors exist, and this area certainly
does not meet the normal criteria for a Chemical Reviews article. However, most of these …

4-(3-Bromoanilino)-6, 7-dimethoxyquinazoline (32, PD 153035) is a very potent inhibitor
(IC50 0.025 nM) of the tyrosine kinase activity of the epidermal growth factor receptor …