Cancer vaccines: Building a bridge over troubled waters
MLC Sellars, CJ Wu, EF Fritsch - Cell, 2022 - cell.com
Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review
the essential immunologic concepts underpinning natural immunity and highlight the …
the essential immunologic concepts underpinning natural immunity and highlight the …
TGF-β Regulation of T Cells
WJ Chen - Annual review of immunology, 2023 - annualreviews.org
Transforming growth factor β (TGF-β) is a key cytokine regulating the development,
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …
activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains …
CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer's disease pathology
Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …
innate immune-mediated inflammation, but functional and mechanistic effects of the …
The evolving role of tissue-resident memory T cells in infections and cancer
S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …
tissues. TRM form an integral part of the immune sensing network and have the ability to …
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells
Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized
infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue …
infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue …
Human circulating and tissue-resident memory CD8+ T cells
Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …
intravascular space. However, emerging data are starting to challenge some of the dogmas …
T cell receptor signaling strength establishes the chemotactic properties of effector CD8+ T cells that control tissue-residency
Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated
effector T cells, but the mechanisms that control the extent of TRM differentiation within …
effector T cells, but the mechanisms that control the extent of TRM differentiation within …
Infection induces tissue-resident memory NK cells that safeguard tissue health
Tissue health is dictated by the capacity to respond to perturbations and then return to
homeostasis. Mechanisms that initiate, maintain, and regulate immune responses in tissues …
homeostasis. Mechanisms that initiate, maintain, and regulate immune responses in tissues …
A multi-use deep learning method for CITE-seq and single-cell RNA-seq data integration with cell surface protein prediction and imputation
CITE-seq, a single-cell multi-omics technology that measures RNA and protein expression
simultaneously in single cells, has been widely applied in biomedical research, especially in …
simultaneously in single cells, has been widely applied in biomedical research, especially in …
Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool
M von Hoesslin, M Kuhlmann, GP de Almeida… - Science …, 2022 - science.org
Resident T lymphocytes (TRM) protect tissues during pathogen reexposure. Although TRM
phenotype and restricted migratory pattern are established, we have a limited understanding …
phenotype and restricted migratory pattern are established, we have a limited understanding …