Neurodegenerative diseases (NDs) constitute a global challenge to human health and an
important social and economic burden worldwide, mainly due to their growing prevalence in …

Proteins are central to life functions. Alterations in the structure of proteins are reflected in
their function. Misfolded proteins and their aggregates present a significant risk to the cell …

Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …

Impairment of autophagic–lysosomal pathways is increasingly being implicated in
Parkinson's disease (PD). GBA1 mutations cause the lysosomal storage disorder Gaucher …

Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder
characterized by motor and non-motor disturbances as a result of a complex and not fully …

Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease. Inflammation has been observed in both the idiopathic and familial …

Recent evidence highlights Parkinson's disease (PD) initiation in the gut as the prodromal
phase of neurodegeneration. Gut impairment due to microbial dysbiosis could affect PD …

Parkinson's disease (PD) is one of the progressive neurological diseases which affect
around 10 million population worldwide. The clinical manifestation of motor symptoms in PD …