Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

The amyloid hypothesis of Alzheimer's disease has long been the predominant theory,
suggesting that Alzheimer's disease is caused by the accumulation of amyloid beta protein …

The mitogen-activated protein kinases (MAPKs) in mammals include c-Jun NH 2-terminal
kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes …

Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the
mitogen-activated protein kinase (MAPK) phosphorylation cascade, an integral module in a …

Mitochondrial dysfunction and synaptic damage are early pathological features of the
Alzheimer's disease-affected brain. Memory impairment in Alzheimer's disease is a …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease
(AD). Mitophagy, a selective autophagy for eliminating damaged mitochondria, constitutes a …

Mitochondrial permeability transition pore (mPTP) plays a central role in alterations of
mitochondrial structure and function leading to neuronal injury relevant to aging and …

Mitochondrial dysfunction is one of the earliest and most prominent features in the brains of
Alzheimer's disease (AD) patients. Recent studies suggest that mitochondrial dysfunction …