There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

Recent discoveries implicate the classical complement cascade in normal brain
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …

Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

Objectives We aimed at investigating the whole-blood transcriptome, expression quantitative
trait loci (eQTLs), and levels of selected serological markers in patients with SLE versus …

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with a
complex pathogenesis. Neuropsychiatric systemic lupus erythematosus (NPSLE) is a …

Neuropsychiatric disease is one of the most common manifestations of human systemic
lupus erythematosus, but the mechanisms remain poorly understood. In human brain …

Complement pathway over-activation has been implicated in a variety of neurological
diseases. However, the signaling pathways governing astrocytic complement activation in …

Introduction The aim of this narrative review is to provide an overview of the literature on the
possible immunologic pathophysiology of psychiatric manifestations of neuropsychiatric …