Revolutionizing drug formulation development: the increasing impact of machine learning
Over the past few years, the adoption of machine learning (ML) techniques has rapidly
expanded across many fields of research including formulation science. At the same time …
expanded across many fields of research including formulation science. At the same time …
State-of-the-art review of artificial neural networks to predict, characterize and optimize pharmaceutical formulation
S Wang, J Di, D Wang, X Dai, Y Hua, X Gao, A Zheng… - Pharmaceutics, 2022 - mdpi.com
During the development of a pharmaceutical formulation, a powerful tool is needed to extract
the key points from the complicated process parameters and material attributes. Artificial …
the key points from the complicated process parameters and material attributes. Artificial …
[HTML][HTML] Lipid based formulations as supersaturating oral delivery systems: from current to future industrial applications
Lipid-based formulations, in particular supersaturated lipid-based formulations, are
important delivery approaches when formulating challenging compounds, as especially low …
important delivery approaches when formulating challenging compounds, as especially low …
Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water
The poor water solubility of active pharmaceutical ingredients (APIs) is a major challenge in
the pharmaceutical industry. Co-solvents are sometimes added to enhance drug dissolution …
the pharmaceutical industry. Co-solvents are sometimes added to enhance drug dissolution …
[HTML][HTML] Advancing algorithmic drug product development: Recommendations for machine learning approaches in drug formulation
JD Murray, JJ Lange, H Bennett-Lenane… - European Journal of …, 2023 - Elsevier
Artificial intelligence is a rapidly expanding area of research, with the disruptive potential to
transform traditional approaches in the pharmaceutical industry, from drug discovery and …
transform traditional approaches in the pharmaceutical industry, from drug discovery and …
Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …
invasive, easy to administer, and easy to store. However, drug formulation for oral …
A dataset of formulation compositions for self-emulsifying drug delivery systems
J Zaslavsky, C Allen - Scientific Data, 2023 - nature.com
Self-emulsifying drug delivery systems (SEDDS) are a well-established formulation strategy
for improving the oral bioavailability of poorly water-soluble drugs. Traditional development …
for improving the oral bioavailability of poorly water-soluble drugs. Traditional development …
Comparative Analysis of Chemical Descriptors by Machine Learning Reveals Atomistic Insights into Solute–Lipid Interactions
This study explores the research area of drug solubility in lipid excipients, an area
persistently complex despite recent advancements in understanding and predicting …
persistently complex despite recent advancements in understanding and predicting …
The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?
P Bannigan, RJ Hickman… - Advanced Healthcare …, 2024 - Wiley Online Library
Over the last four decades, pharmaceutical companies' expenditures on research and
development have increased 51‐fold. During this same time, clinical success rates for new …
development have increased 51‐fold. During this same time, clinical success rates for new …
[HTML][HTML] Predictive computational models for assessing the impact of co-milling on drug dissolution
N Pätzmann, PJ O'Dwyer, J Beránek, M Kuentz… - European Journal of …, 2024 - Elsevier
Co-milling is an effective technique for improving dissolution rate limited absorption
characteristics of poorly water-soluble drugs. However, there is a scarcity of models …
characteristics of poorly water-soluble drugs. However, there is a scarcity of models …