Revolutionizing drug formulation development: the increasing impact of machine learning

Z Bao, J Bufton, RJ Hickman, A Aspuru-Guzik… - Advanced Drug Delivery …, 2023 - Elsevier
Over the past few years, the adoption of machine learning (ML) techniques has rapidly
expanded across many fields of research including formulation science. At the same time …

State-of-the-art review of artificial neural networks to predict, characterize and optimize pharmaceutical formulation

S Wang, J Di, D Wang, X Dai, Y Hua, X Gao, A Zheng… - Pharmaceutics, 2022 - mdpi.com
During the development of a pharmaceutical formulation, a powerful tool is needed to extract
the key points from the complicated process parameters and material attributes. Artificial …

[HTML][HTML] Lipid based formulations as supersaturating oral delivery systems: from current to future industrial applications

R Holm, M Kuentz, AR Ilie-Spiridon, BT Griffin - European Journal of …, 2023 - Elsevier
Lipid-based formulations, in particular supersaturated lipid-based formulations, are
important delivery approaches when formulating challenging compounds, as especially low …

Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water

A Zarei, R Haghbakhsh, S Raeissi - European Journal of Pharmaceutics …, 2023 - Elsevier
The poor water solubility of active pharmaceutical ingredients (APIs) is a major challenge in
the pharmaceutical industry. Co-solvents are sometimes added to enhance drug dissolution …

[HTML][HTML] Advancing algorithmic drug product development: Recommendations for machine learning approaches in drug formulation

JD Murray, JJ Lange, H Bennett-Lenane… - European Journal of …, 2023 - Elsevier
Artificial intelligence is a rapidly expanding area of research, with the disruptive potential to
transform traditional approaches in the pharmaceutical industry, from drug discovery and …

Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method

ALJ Khater, SH Almurisi, S Mahmood… - International Journal of …, 2023 - Elsevier
Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

A dataset of formulation compositions for self-emulsifying drug delivery systems

J Zaslavsky, C Allen - Scientific Data, 2023 - nature.com
Self-emulsifying drug delivery systems (SEDDS) are a well-established formulation strategy
for improving the oral bioavailability of poorly water-soluble drugs. Traditional development …

Comparative Analysis of Chemical Descriptors by Machine Learning Reveals Atomistic Insights into Solute–Lipid Interactions

JJ Lange, A Anelli, J Alsenz, M Kuentz… - Molecular …, 2024 - ACS Publications
This study explores the research area of drug solubility in lipid excipients, an area
persistently complex despite recent advancements in understanding and predicting …

The Dawn of a New Pharmaceutical Epoch: Can AI and Robotics Reshape Drug Formulation?

P Bannigan, RJ Hickman… - Advanced Healthcare …, 2024 - Wiley Online Library
Over the last four decades, pharmaceutical companies' expenditures on research and
development have increased 51‐fold. During this same time, clinical success rates for new …

[HTML][HTML] Predictive computational models for assessing the impact of co-milling on drug dissolution

N Pätzmann, PJ O'Dwyer, J Beránek, M Kuentz… - European Journal of …, 2024 - Elsevier
Co-milling is an effective technique for improving dissolution rate limited absorption
characteristics of poorly water-soluble drugs. However, there is a scarcity of models …