Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
Where are the disease-associated eQTLs?
Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …
have detectable effects on gene expression. One explanation could be that we have not …
Whole-genome duplication in teleost fishes and its evolutionary consequences
SMK Glasauer, SCF Neuhauss - Molecular genetics and genomics, 2014 - Springer
Whole-genome duplication (WGD) events have shaped the history of many evolutionary
lineages. One such duplication has been implicated in the evolution of teleost fishes, by far …
lineages. One such duplication has been implicated in the evolution of teleost fishes, by far …
Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest …
SL Pearce, DF Clarke, PD East, S Elfekih, KHJ Gordon… - BMC biology, 2017 - Springer
Abstract Background Helicoverpa armigera and Helicoverpa zea are major caterpillar pests
of Old and New World agriculture, respectively. Both, particularly H. armigera, are extremely …
of Old and New World agriculture, respectively. Both, particularly H. armigera, are extremely …
Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
The completion of the Arabidopsis thaliana genome sequence allows a comparative
analysis of transcriptional regulators across the three eukaryotic kingdoms. Arabidopsis …
analysis of transcriptional regulators across the three eukaryotic kingdoms. Arabidopsis …
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
V Garg, IS Kathiriya, R Barnes, MK Schluterman… - Nature, 2003 - nature.com
Congenital heart defects (CHDs) are the most common developmental anomaly and are the
leading non-infectious cause of mortality in newborns. Only one causative gene, NKX2-5 …
leading non-infectious cause of mortality in newborns. Only one causative gene, NKX2-5 …
The evolution of transcriptional regulation in eukaryotes
Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …
an important component of the genetic basis for evolutionary change in diverse aspects of …
[图书][B] Nature via nurture: Genes, experience, and what makes us human.
M Ridley - 2003 - psycnet.apa.org
Published fifty years after the discovery of the double helix of DNA, this book chronicles a
revolution in our understanding of genes. The author recounts the hundred years' war …
revolution in our understanding of genes. The author recounts the hundred years' war …
Transposable element influences on gene expression in plants
CD Hirsch, NM Springer - Biochimica et Biophysica Acta (BBA)-Gene …, 2017 - Elsevier
Transposable elements (TEs) comprise a major portion of many plant genomes and bursts
of TE movements cause novel genomic variation within species. In order to maintain proper …
of TE movements cause novel genomic variation within species. In order to maintain proper …
Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
Divergent morphology of species has largely been ascribed to genetic differences in the
tissue-specific expression of proteins, which could be achieved by divergence in cis …
tissue-specific expression of proteins, which could be achieved by divergence in cis …