Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be
developed with high affinity and specificity to interact with any desired targets. They have …

Nucleolin or C23, is one of the most abundant non-ribosomal phosphoproteins of nucleolus.
However, in several cancers, nucleolin is highly expressed both intracellularly and on the …

Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases,
due to the lack of early diagnosis, and high relapse rate after conventional therapies …

Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Tetrahedral DNA nanostructures (TDNs) are considered promising drug delivery carriers
because they are able to permeate cellular membrane and are biocompatible and …

Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest.
Aptamers have been identified as candidates for the construction of various smart systems …

Galectins are animal lectins with specific affinity for galactosides via the conserved
carbohydrate recognition domains. Increasing studies recently have identified critical roles …

Traditional anticancer therapies can cause serious side effects in clinical treatment due to
their nonspecific of tumor cells. Aptamers, also termed as' chemical antibodies', are short …

Gemcitabine has been considered a first-line chemotherapy agent for the treatment of
pancreatic cancer. However, the initial response rate of gemcitabine is low and …

Active targeting of nanostructures containing chemotherapeutic agents can improve cancer
treatment. Here, a three-way junction pocket DNA nanostructure was developed for efficient …