Invariant natural killer T (iNKT) cells are a specialized T cell subset that plays an important
role in host defense, orchestrating both innate and adaptive immune effector responses …

Most fungi are capable of disseminating into the central nervous system (CNS) commonly
being observed in immunocompromised hosts. Microglia play a critical role in responding to …

Human fungal pathogens that cause invasive infections are hidden killers, taking lives of
one and a half million people every year. However, research progress in this field has not …

Microglia provide protection against a range of brain infections including bacteria, viruses
and parasites, but how these glial cells respond to fungal brain infections is poorly …

Microglia are the primary immunocompetent cells of the central nervous system (CNS). Their
ability to survey, assess and respond to perturbations in their local environment is critical in …

The scavenger receptor macrophage receptor with collagenous structure (MARCO)
promotes protective innate immunity against bacterial and parasitic infections; however, its …

C-type lectin receptors (CLRs) are diverse, trans-membrane proteins that function as pattern
recognition receptors (PRRs) which are necessary for orchestrating immune responses …

Background Paradoxical cryptococcosis-associated immune reconstitution inflammatory
syndrome (C-IRIS) affects~ 25% of human immunodeficiency virus (HIV)-infected patients …

Transcription factors are key players in the control of the activation or repression of gene
expression programs in response to environmental stimuli. The study of regulatory networks …

Interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β) are pro-inflammatory cytokines that
are induced after Cryptococcus neoformans infection and activate the interleukin-1 receptor …