The immune system probably evolved to limit the negative effects exerted by pathogens on
host homeostasis. This defence strategy relies on the concerted action of innate and …

Microbial communities are spatially organized in both the environment and the human body.
Although patterns exhibited by these communities are described by microbial biogeography …

In a healthy host, a balance exists between members of the microbiota, such that potential
pathogenic and non-pathogenic organisms can be found in apparent harmony. During …

In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior
nares of 20–80% of the human population. The relationship between host and microbe …

In this review, we examine the current status of S taphylococcus aureus vaccine
development and the prospects for future vaccines. Examination of the clinical trials to date …

A fundamental puzzle in immunology is how the immune system decides what types of
immune responses to launch against different stimuli. Although much is known about control …

Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and
Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a …

Superantigens (SAgs) are a family of potent immunostimulatory exotoxins known to be
produced by only a few bacterial pathogens, including Staphylococcus aureus. More than …

Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

The skin is constantly exposed to various endogenous and exogenous factors that may
impact the barrier function at the physical, mechanical, and microbial levels. These factors …