Disease tolerance and immunity in host protection against infection
The immune system probably evolved to limit the negative effects exerted by pathogens on
host homeostasis. This defence strategy relies on the concerted action of innate and …
host homeostasis. This defence strategy relies on the concerted action of innate and …
The biogeography of polymicrobial infection
Microbial communities are spatially organized in both the environment and the human body.
Although patterns exhibited by these communities are described by microbial biogeography …
Although patterns exhibited by these communities are described by microbial biogeography …
Microbiota restoration: natural and supplemented recovery of human microbial communities
G Reid, JA Younes, HC Van der Mei… - Nature Reviews …, 2011 - nature.com
In a healthy host, a balance exists between members of the microbiota, such that potential
pathogenic and non-pathogenic organisms can be found in apparent harmony. During …
pathogenic and non-pathogenic organisms can be found in apparent harmony. During …
Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design
AF Brown, JM Leech, TR Rogers… - Frontiers in …, 2014 - frontiersin.org
In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior
nares of 20–80% of the human population. The relationship between host and microbe …
nares of 20–80% of the human population. The relationship between host and microbe …
Where does a Staphylococcus aureus vaccine stand?
VG Fowler Jr, RA Proctor - Clinical Microbiology and Infection, 2014 - Wiley Online Library
In this review, we examine the current status of S taphylococcus aureus vaccine
development and the prospects for future vaccines. Examination of the clinical trials to date …
development and the prospects for future vaccines. Examination of the clinical trials to date …
Programming dendritic cells to induce TH2 and tolerogenic responses
B Pulendran, H Tang, S Manicassamy - Nature immunology, 2010 - nature.com
A fundamental puzzle in immunology is how the immune system decides what types of
immune responses to launch against different stimuli. Although much is known about control …
immune responses to launch against different stimuli. Although much is known about control …
MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their …
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and
Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a …
Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a …
Staphylococcal superantigens in colonization and disease
SX Xu, JK McCormick - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Superantigens (SAgs) are a family of potent immunostimulatory exotoxins known to be
produced by only a few bacterial pathogens, including Staphylococcus aureus. More than …
produced by only a few bacterial pathogens, including Staphylococcus aureus. More than …
Manipulation of innate and adaptive immunity by staphylococcal superantigens
SW Tuffs, SMM Haeryfar, JK McCormick - Pathogens, 2018 - mdpi.com
Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …
The role of cutaneous microbiota harmony in maintaining a functional skin barrier
HE Baldwin, NC Bhatia, A Friedman, T Prunty… - SKIN The Journal of …, 2017 - jofskin.org
The skin is constantly exposed to various endogenous and exogenous factors that may
impact the barrier function at the physical, mechanical, and microbial levels. These factors …
impact the barrier function at the physical, mechanical, and microbial levels. These factors …