Base editing by CRISPR crucially depends on the presence of a protospacer adjacent motif
(PAM) at the correct distance from the editing site. Here, we present and validate an efficient …

RNA 编辑, 即通过碱基的插入, 删除和替换对RNA 进行的转录后加工过程,
这一表观遗传现象也被认为是在RNA 水平上对遗传信息进行修复的一种修正机制 …

棉花是全球重要的经济作物和纺织工业原料, 选育优良新品种是提高棉花产量,
品质和植棉效益的主要途径. 然而, 传统育种方法在改良作物遗传特性方面存在很大的局限性 …

The CRISPR/Cas9 system has proven to be highly valuable for genome editing in several
important crops, including the allogamous tetraploid cultivated alfalfa (Medicago sativa) …

CRISPR-dependent base editors enable direct nucleotide conversion without the
introduction of double-strand DNA break or donor DNA template, thus expanding the …

全球气候变化, 人口增长, 耕地减少和极端天气频发等为粮食安全和农业可持续发展带来诸多
挑战. 以CRISPR/Cas 为代表的基因组编辑技术能够快速定向创制农作物新种质, 提高育种效率 …

CRISPR/Cas9 systems and recently established base editors are essential tools for precise,
targeted genome editing for translational and basic research applications. Here we present …

The development of new adaptations of CRISPR-based genome editing platforms, such as
base editing and prime editing, made it possible to broaden the scope and applications of …

Cotton is a globally important cash crop and a crucial raw material for the textile industry.
Breeding superior cultivars is the primary approach for increasing cotton yield, fiber quality …

The CRISPR/Cas gene-editing technology is a groundbreaking tool that enables
researchers to accurately modify the DNA of an organism (El-Mounadi et al. 2020). The …