Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Preservation of female genetics is currently done primarily by means of oocyte and embryo
cryopreservation. The field has seen much progress during its four-decade history, progress …

Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa,
and in some species, co-occurs with genetic sex determination (GSD) mechanisms …

Zebrafish are an established research organism that has made many contributions to our
understanding of vertebrate tissue and organ development, yet there are still significant …

The classical view of ovarian follicle development is that it is regulated by the hypothalamic-
pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the …

Continuation of mammalian species requires the formation and development of the sexually
dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent …

Primary ovarian insufficiency (POI) is determined by exhaustion of follicles in the ovaries,
which leads to infertility before the age of 40 years. It is characterized by a strong familial …

Prior to activation of the embryonic genome, the initiating events of mammalian development
are under maternal control and include fertilization, the block to polyspermy and processing …

Primordial follicles are formed perinatally in mammalian ovaries and at birth represent the
lifetime complement of germ cells. With cyclic periodicity, cohorts enter into a growth phase …

The development of both the mammalian oocyte and the somatic cell compartments of the
ovarian follicle is highly coordinated; this coordination ensures that the ovulated oocyte is …